Linker-Toxin SET, INNO-206 (Aldoxorubicin) is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
More Information Supplier PageLinker-Toxin SET, INNO-206 (Aldoxorubicin) is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, doxorubicin prodrug INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety.
More Information Supplier PageADCs Toxins, Tubastatin A hydrochloride is a potent and selective inhibitor of HDAC6. IC50=15 nM. Tubastatin A HCl induced the acetylation of [alpha]-tubulin and protected primary cortical neurons against glutathione depletion-induced oxidative stress.
More Information Supplier PageADCs Toxins, Triptolin A is described as an specific non-ATP competitve Aurora A kinase inhibitor. Tripolin A doesn`t significantly inhibit Aurora B kinase in mammalian cells. Tripolin A reduces localization of pAurora A on spindle microtubules, affects centrosome integrity, spindle formation and lenght and MT dynamitcs in interphase. Tripolin A is a novel small molecule […]
More Information Supplier PageADCs Toxins, Thiocolchicine is an antimitotic alkaloide. Thiocolchicine is an inhibitor of microtubules by specific binding to tubulin.Thiocolchicine is a topoisomerase I inhibitor.
More Information Supplier PageADCs Toxins, Myoseverin is a microtubule-binding molecule and a reversible inhibitor of tubulin polymerization. Myoseverin is a potential angiogenesis inhibitor.
More Information Supplier PageADCs Toxins, Microcystin LR is a cyclic heptapeptide produced by the species of cyanobacteria Microcystis. Microcystin exhibits cytotoxic, carcinogenic and pro-oxidateive properties.
More Information Supplier PageADCs Toxins, Mensacarcin is an antitumor compund. Mensacarcin has cytotoxic activity (TGI 1.3 µM, NCI standard). Furthermore Mensacarcin is described as an antibiotic compound. Mensacarcin is isolated from Streptomyces bottropensis
More Information Supplier PageADCs Toxins, Mechercharmycin A is a cytotoxic compound with antitumor activitiy. It is a marine-derived Thermoactinomyces sp. HCT-116: IC50=0,0014 µM; PSN1 : IC50=0,007 µM; T98G : IC50=0,014 µM; A549 : IC50=0,007 µM (preliminary laboratory results). Journal of Antibiotics (2005), 58(4), 289-292.
More Information Supplier PageADCs Toxins, Luisol A shows weak cytotoxic activities against tumor cell lines. Luisol A has antiparasitic activity.
More Information Supplier Page
