Creative Biolabs
ADCs Toxins, Quinaldopeptin is a quinomycin antibiotic isolated from an Amycolatopsis sp. with strong antimicrobial and cytotoxic activity. The symmetric cyclic peptide structure of Quinaldopeptin contains two intercalating naphtyl moieties which produce a bis-intercalation of DNA base pairs, creating DNA crosslinks and disturbing natural DNA processes. Quinaldopeptin is demonstrated to have high efficacy against gram-positive […]
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Creative Biolabs
ADCs Toxins, epsilon-Amanitin is a cyclic peptide, found i.e. in the Amanita genus of mushrooms. Oral LD50 is in the range of 0.1 mg/kg.
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Creative Biolabs
Creative Biolabs
ADCs Toxins, Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer […]
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Creative Biolabs
ADCs Toxins, Sinefungin blocks the methylation of bases in DNA and RNA. Sinefungin is also involved in physiological processes such as aging and carcinogenesis.
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Creative Biolabs
ADCs Toxins, Telomestatin is described as an very effective compound with antitumor effects. Telomestatin has been tested to have an IC50 value of 50 nM and therefore it is an very strong telomerase inhibitor.
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Creative Biolabs
Creative Biolabs
Creative Biolabs
Creative Biolabs
ADCs linker, 6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates.
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