Linker-Toxin SET, Monomethylauristatin F(MMAF) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than MMAE; Mc-MMAF is a protective group (maleimidocaproyl) -conjugated MMAF.
More Information Supplier PageLinker-Toxin SET, This set is made by MMAE conjugated to MC-vc-PAB linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.
More Information Supplier PageLinker-Toxin SET, This set is made by DM1 conjugated to SMCC linker. DM1 belongs to Maytansinoids which are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in […]
More Information Supplier PageLinker-Toxin SET, VcMMAE is an antibody-drug conjugate (ADC) with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
More Information Supplier PageLinker-Toxin SET, Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
More Information Supplier PageADCs Toxins, Sanguinarine is a natrually isolated benzophenanthridine alkaloide. Sanguinarine exhibits several beneficial properties like: chemotherapeutic, anti-inflammatory and antibacterial activities. Sanguinarine increases oxidative stress and induces DNA damage in species of Microcystatis, a cyanobacterium, inhibiting cell division.
More Information Supplier PageADCs Toxins, The small molecule Rebeccamycin is an indolocarbazole antibiotic, functional as an inhibitor DNA topoisomerase I. The stereochemistry of the pendant sugar on Rebeccamycin is demonstrated to be crucial for the specificity of this DNA interaction. HCT-116: IC50=0,000082 uM; PSN1 : IC50=0,041 uM; T98G : IC50=0,00082 uM; A549 : IC50=0,00041 uM (preliminary laboratory results).
More Information Supplier PageADCs Toxins, Safracin B is an novel antibiotic compound produced by Pseudomonas fluorescens. Safracin B showed antitumor activity against L1210 and P388 leukemias and B16 melanoma.Early research indicates that the alpha-carbinolamine structure may plays an important role in the antitumor action of this type of antibiotic.
More Information Supplier PageADCs Toxins, Ro 5-3335 is described to kill human leukemia cell lines with CBF fusion proteins. The IC50 value – 1.1 µM.
More Information Supplier PageADCs Toxins, An antibiotic composed of a halogenated indolocarbazole chromophore linked via N-glycosidic bond to a glucose derivative. It intercalates into the DNA and is an inhibitor of topoisomerase I. L1210: IC50 = 100 nM (mouse); K562: IC50 = 200 nM (human); A549: IC50 = 300 nM (human); B16 melanoma cells: IC50 = 480 nM […]
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