Salirasib (Farnesylthiosalicylic acid, FTS) is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Salirasib exerts antitumor effects and induces autophagy. Phase 2.
More Information Supplier PageSecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.
More Information Supplier PageML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 […]
More Information Supplier PageML141 (CID-2950007) is demonstrated to be a potent, selective and reversible non-competitive inhibitor of Cdc42 GTPase suitable for in vitro assays, with IC50 of 200 nM and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 is associated with an increase in p38 activation and may induce p38-dependent apoptosis/senescence. ML141 […]
More Information Supplier PageLY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.
More Information Supplier PageLY2584702 is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM.
More Information Supplier PageDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
More Information Supplier PageDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
More Information Supplier PageDefactinib (VS-6063, PF-04554878) is a selective, and orally active FAK inhibitor. Phase 2.
More Information Supplier PageKartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
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