Fosbretabulin disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature.
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Palmitic acid, a natural product isolated and purified from the herbs of Atractylodes macrocephala Koidz., induces down-regulation of APOM expression and anxiety-like behavior in mice while increasing amygdala-based serotonin metabolism. Palmitic acid has a significant impact on proliferation and differentiation of NSCs in vitro and may be useful for elucidating the role of SFAs in […]
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Isochlorogenic acid C, a natural product isolated and purified from the herbs of Laggera alata, possesses potent hepatoprotective and anti-HBV, anti-HCV, and anti-HIV effects.
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Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities.
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Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities.
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Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities.
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Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities.
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Paeonol is a naturally occuring MAO inhibitor with IC50 values of 54.6 μM and 42.5 μM for MAO-A and MAO-B, respectively.
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