The biological activity of Jervine is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
More Information Supplier Page
Antitumor agent-21 (TRX818) is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities.
More Information Supplier Page
Secoisolariciresinol Diglucoside was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol Diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect by preventing the liver from peroxidation damage through inhibition of ROS level mediated increased level of enzymatic and non-enzymatic antioxidants.
More Information Supplier Page
Importazole is an inhibitor of the nuclear transport receptor importin-β.
More Information Supplier Page
ARQ-092 is an orally bioavailable, selective, and potent allosteric Akt inhibitor.
More Information Supplier Page
Clofentezine is an active substance of plant protection product used as the pesticide, acaricide.
More Information Supplier Page
Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
More Information Supplier Page
Ocaperidona (Ocaperidone), a very high affinity dopamine D2 antagonist.
More Information Supplier Page
Piribedil is a dopamine D2 agonist, used in the treatment of Parkinson’s disease.
More Information Supplier Page
