Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
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Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.
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CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
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CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
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BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
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BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
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BTB-1 (NSC156750) is a novel small molecule inhibitor of the mitotic motor protein Kif18A.
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ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
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ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
More Information Supplier Page ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.
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