TSU-68, a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2 and does not suppresses EGFR.
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Vilazodone HCl, a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.
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Vilazodone HCl, a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.
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LEE011 is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).
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LEE011 is an orally available, and highly specific CDK4/6 inhibitor (IC50：10/39 nM).
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PP1, a specific and effective Src inhibitor, is with IC50 for Lck/Fyn is 5 nM/ 6 nM, respectively.
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Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
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Tasisulam is an apoptosis inducer and an antitumor agent via the intrinsic pathway.
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PD0325901 is a specific and non-ATP-competitive MEK inhibitor (IC50: 0.33 nM).
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GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.
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