Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and […]
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Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
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Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
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2, 4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist.
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2, 4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist.
More Information Supplier Page 2, 4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist.
More Information Supplier Page 2, 4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist.
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2, 4-methanoglutamate is a potent and selective N-methyl-D-aspartate receptor agonist.
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Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
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CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation. CC-223 is a potent mTOR kinase inhibitor (IC50: 16 nM), with >150-fold sensitivity than the related lipid kinase PI3Kα (IC50: 4 […]
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