BAY 1000394 (Roniciclib) is a potent inhibitor of pan-CDK, that inhibits the kinase activity of the cell-cycle cyclin-dependent kinases (CDKs), with IC50 of 7, 9, 11, 25 and 5 nmol/L for CDK1, CDK2, CDK4, CDK7 and CDK9, respectively. It induces cell-cycle arrest and apoptosis and exhibits potent antitumor activity.
More Information Supplier PageSenaparib(IMP4297, JS109) is a potent, selective and orally active PARP1/2 inhibitor with strong antitumor activity in preclinical studies.
More Information Supplier PageDigitoxin is an anti-cancer agent. Digitoxin induces apoptosis, inhibits influenza cytokine storm, causes DNA double-stranded breaks (DSBs) and blocks the cell cycle at the G2/M phase. Digitoxin induces calcium uptake into cells by forming transmembrane calcium channels and can be used for research of heart failure .
More Information Supplier PageCalcium chloride (CaCl2) is an ionic compound used for calcium supplementation in conditions like hypocalcemia and hyperkalemia and as an antidote for magnesium toxicity. It also functions as a co-adjuvant in hemostatic formulations and effectively treats refractory hypotension and complete heart block. It enhances the activity of MoPtc1 and MoPtc2, type 2C protein phosphatases involved […]
More Information Supplier PageMD-224 is a highly potent and effective degrader of the Human murine double minute 2 (MDM2) protein, the main cellular inhibitor of the tumor suppressor p53. It strongly inhibits cell growth in leukemia cell lines with wild-type p53 and induces complete and lasting tumor regression in the RS4;11 xenograft tumor model.
More Information Supplier PageSenaparib(IMP4297, JS109) is a potent, selective and orally active PARP1/2 inhibitor with strong antitumor activity in preclinical studies.
More Information Supplier PageMD-224 is a highly potent and effective degrader of the Human murine double minute 2 (MDM2) protein, the main cellular inhibitor of the tumor suppressor p53. It strongly inhibits cell growth in leukemia cell lines with wild-type p53 and induces complete and lasting tumor regression in the RS4;11 xenograft tumor model.
More Information Supplier PageMD-224 is a highly potent and effective degrader of the Human murine double minute 2 (MDM2) protein, the main cellular inhibitor of the tumor suppressor p53. It strongly inhibits cell growth in leukemia cell lines with wild-type p53 and induces complete and lasting tumor regression in the RS4;11 xenograft tumor model.
More Information Supplier PageCPI-1612 is a highly potent, orally active inhibitor of EP300/CBP histone acetyltransferase (HAT). It displays an IC50 of 8.0 nM for EP300 HAT. CPI-1612 suppresses H3K27 acetylation in vivo and exhibits efficacy in JEKO-1 mantle cell lymphoma xenograft at a low dose. CPI-1612 displays anticancer activity.
More Information Supplier PageMD-224 is a highly potent and effective degrader of the Human murine double minute 2 (MDM2) protein, the main cellular inhibitor of the tumor suppressor p53. It strongly inhibits cell growth in leukemia cell lines with wild-type p53 and induces complete and lasting tumor regression in the RS4;11 xenograft tumor model.
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