Chicoric acid is an orally active dicaffeoyltartaric acid with antioxidant, anti-inflammatory, and antidiabetic properties. It induces ROS generation and triggers mitochondria-dependent apoptosis in 3T3-L1 preadipocytes via PI3K/Akt and MAPK pathways. It also enhances glucose uptake and improves insulin resistance.

GPR84 antagonist 8 is an antagonist of GPR84,which abrogates the enhanced inflammatory response mediated by 6-OAU. It has the potential to reduce the inflammatory responses associated with the activation of the GPR84 receptor.

GPR84 antagonist 8 is an antagonist of GPR84,which abrogates the enhanced inflammatory response mediated by 6-OAU. It has the potential to reduce the inflammatory responses associated with the activation of the GPR84 receptor.

Iberiotoxin TFA(IbTX) is a toxin purified from the scorpion Buthus tamulus. Iberiotoxin is a potent blocker of the large conductance Ca(2+)-activated K+ channel with a Kd of ~1 nM.

Hispidin is a phenolic compound from Phellinus linteus (a medicinal mushroom) and a potent inhibitor of protein kinase Cβ(PKC) with an IC50 of 2 μM, respectively. It also inhibits beta-secretase (BACE1) and prolyl endopeptidase(PE) with IC50 values of 4.9 μM and 16 μM respectively. It exhibits strong anti-oxidant, anti-cancer, anti-diabetic, anti-dementia, anti-inflammatory, anti-apoptotic, and antiviral […]

Hispidin is a phenolic compound from Phellinus linteus (a medicinal mushroom) and a potent inhibitor of protein kinase Cβ(PKC) with an IC50 of 2 μM, respectively. It also inhibits beta-secretase (BACE1) and prolyl endopeptidase(PE) with IC50 values of 4.9 μM and 16 μM respectively. It exhibits strong anti-oxidant, anti-cancer, anti-diabetic, anti-dementia, anti-inflammatory, anti-apoptotic, and antiviral […]

REGN5678 is a bispecific antibody targeting both PSMA on prostate cancer cells and CD28 on T-cells to enhance immune activation. It is being developed for the treatment of prostate cancer by redirecting T-cells to PSMA-expressing tumors, promoting tumor cell death. M.W 145.86 kDa

Iberiotoxin TFA(IbTX) is a toxin purified from the scorpion Buthus tamulus. Iberiotoxin is a potent blocker of the large conductance Ca(2+)-activated K+ channel with a Kd of ~1 nM.

Flotetuzumab is a bispecific DART antibody targeting CD123 on tumor cells and CD3ε on T-cells to stimulate immune cell-mediated tumor lysis. It is being developed for the treatment of hematological malignancies by enhancing T-cell responses against CD123-expressing tumors. M.W 58.91 kDa

M701 is a bispecific antibody targeting CD3 on T-cells and EpCAM on tumor cells to stimulate T-cell-mediated tumor cell death. It is being developed for the treatment of malignant ascites by redirecting T-cells to EpCAM-expressing tumors. M.W 125.84 kDa