CXCL12, also known as SCYB12, PBSF and SDF-1 beta, is an 8.3 kDa, heparin-binding member of the CXC (or alpha-) family of chemokines. SDF-1 is highly conserved between species, mouse CXCL12β shares approximately 92 % amino acid sequence identity with human CXCL12β. In all SDF-1 isoforms, SDF-1β is the canonical sequence. It has the complete […]

CXCL12, also known as SDF-1, is a heparin-binding member of the CXC (or alpha-) family of chemokines. SDF-1 alpha and SDF-1 beta are the first cytokines initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line. CXCL12β […]

CXCL12, also known as SCYB12, PBSF and SDF-1 beta, is an 8.3 kDa, heparin-binding member of the CXC (or alpha-) family of chemokines. SDF-1 is highly conserved between species, mouse CXCL12β shares approximately 92 % amino acid sequence identity with human CXCL12β. In all SDF-1 isoforms, SDF-1β is the canonical sequence. It has the complete […]

CXCL12 is belonging to the CXC chemokine family. SDF_x005f_x001e_1 alpha and SDF1 beta cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. SDF-1 is highly conserved between species, mouse CXCL12α shares approximately 93% amino acid sequence identity with human CXCL12α. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. Contrast to […]

CXCL12 is belonging to the CXC chemokine family. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. Contrast to SDF-1β, SDF-1α is shorter by four amino acids at the C-terminal tail. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. SDF-1 is highly conserved between species, rat CXCL12α shares approximately 96% amino acid […]

CXCL11 also known as I-TAC is belonging to the CXC chemokine family. CXCL11, together with MIG and IP-10, constitute a subset of chemokines that are ligands for CXCR3, a chemokine receptor that is primarily expressed on activated Th1 cells and NK cells. Mouse CXCL11 also shares 36% and 29% aa sequence identity with mouse IP-10 […]

CXCL11, also known as I-TAC, SCYB9B, H174 and beta -R1, is a non-ELR CXC chemokine. CXCL11 cDNA encodes a 94 amino acid (aa) residue precursor protein with a 21 aa residue putative signal sequence, which is cleaved to form the mature 73 aa residue protein. CXCL11 shares 36% and 37% amino acid sequence homology with […]

CXCL12, also known as SDF-1, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF-1 alpha and SDF-1 beta are the first cytokines initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. They are identical except for the four […]

Interleukin-8 (IL-8), also known as CXCL8, GCP-1, and NAP-1, is a widely expressed proinflammatory member of the CXC family of chemokines. This 8-9 kDa chemokine circulates as a monomer, homodimer, and heterodimer with CXCL4/PF4. Its oligomerization is modulated by interactions with matrix and cell surface glycosaminoglycans (GAGs). Mature porcine CXCL8 shares 82%, 78%, and 65% […]

C–X–C motif chemokine 10 (CXCL10) also known as interferon γ-induced protein 10kDa (IP-10) or small-inducible cytokine B10 is a cytokine belonging to the CXC chemokine family. The rhesus macaque IP-10 shares 69 %, 95 %, 74 % a.a. sequence identity with human, mouse, rat IP-10. This chemokine elicits its effects by binding to the cell […]