AMTB hydrochloride is a blocker of the transient receptor potential melastatin 8 (TRPM8) ion channel. It reduces the activation of TRPM8 channels induced by icilin, as assessed through a Ca2+ influx assay, with a pIC50 of 6.23. It is used as a tool to evaluate the role of this channel in bladder rhythmic contraction.

KT-413 (IRAK degrader-1, zomiradomide) is a dual-function PROTAC molecule and a potent degrader of interleukin-1 receptor associated kinase 4 (IRAK4) and the transcription factors Ikaros and Aiolos by acting as both a heterobifunctional degrader and a molecular glue. It can be used in research for developing therapies targeting the activated B-cell (ABC) subtype of diffuse […]

KT-413 (IRAK degrader-1, zomiradomide) is a dual-function PROTAC molecule and a potent degrader of interleukin-1 receptor associated kinase 4 (IRAK4) and the transcription factors Ikaros and Aiolos by acting as both a heterobifunctional degrader and a molecular glue. It can be used in research for developing therapies targeting the activated B-cell (ABC) subtype of diffuse […]

KT-413 (IRAK degrader-1, zomiradomide) is a dual-function PROTAC molecule and a potent degrader of interleukin-1 receptor associated kinase 4 (IRAK4) and the transcription factors Ikaros and Aiolos by acting as both a heterobifunctional degrader and a molecular glue. It can be used in research for developing therapies targeting the activated B-cell (ABC) subtype of diffuse […]

KT-413 (IRAK degrader-1, zomiradomide) is a dual-function PROTAC molecule and a potent degrader of interleukin-1 receptor associated kinase 4 (IRAK4) and the transcription factors Ikaros and Aiolos by acting as both a heterobifunctional degrader and a molecular glue. It can be used in research for developing therapies targeting the activated B-cell (ABC) subtype of diffuse […]

O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs.

O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs.

O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs.

O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs.

NMD670 is a first-in-class small molecule inhibitor of skeletal muscle-specific chloride channel (ClC-1) with an EC50 of 1.6 μM. It improves muscle weakness and fatigue in neuromuscular diseases and may serve as a potential therapeutic approach for Myasthenia Gravis (MG).