OPB-171775 functions as a molecular glue, promoting the formation of a complex between phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12). This interaction triggers multiple cellular stresses, ultimately leading to cell death. It also demonstrates significant anticancer activity in patient-derived xenograft (PDX) models of Gastrointestinal stromal tumor (GIST).

EVT801 is a potent and selective inhibitor of VEGFR-3 with an IC50 of 11 nM. It exhibits potent antitumor effects and represents a promising anti-lymphangiogenic drug in patients with VEGFR-3 positive tumors.

EVT801 is a potent and selective inhibitor of VEGFR-3 with an IC50 of 11 nM. It exhibits potent antitumor effects and represents a promising anti-lymphangiogenic drug in patients with VEGFR-3 positive tumors.

EVT801 is a potent and selective inhibitor of VEGFR-3 with an IC50 of 11 nM. It exhibits potent antitumor effects and represents a promising anti-lymphangiogenic drug in patients with VEGFR-3 positive tumors.

THZ-P1-2 is an inhibitor of PI5P4K, which covalently binds to cysteines on a disordered loop in PI5P4Kα/β/γ. It inhibits PI5P4Kα kinase activity with an IC50 of 190 nM and disrupts autophagy by impairing autophagosome clearance and increasing TFEB nuclear localization.

THZ-P1-2 is an inhibitor of PI5P4K, which covalently binds to cysteines on a disordered loop in PI5P4Kα/β/γ. It inhibits PI5P4Kα kinase activity with an IC50 of 190 nM and disrupts autophagy by impairing autophagosome clearance and increasing TFEB nuclear localization.

EVT801 is a potent and selective inhibitor of VEGFR-3 with an IC50 of 11 nM. It exhibits potent antitumor effects and represents a promising anti-lymphangiogenic drug in patients with VEGFR-3 positive tumors.

THZ-P1-2 is an inhibitor of PI5P4K, which covalently binds to cysteines on a disordered loop in PI5P4Kα/β/γ. It inhibits PI5P4Kα kinase activity with an IC50 of 190 nM and disrupts autophagy by impairing autophagosome clearance and increasing TFEB nuclear localization.

Gingerenone A is a a polyphenol present in ginger, an inhibitor of p70 S6 (S6K1) and an activator of Nrf2-Gpx4 signaling pathway to alleviate ferroptosis in secondary liver injury in colitis. It exhibits anti-adipogenic, anti-lipogenic, anti-hyperglycemic, anti-obesity, and anti-inflammatory effects, and holds promise for research into anti-diabetic and anti-obesity drug development.

THZ-P1-2 is an inhibitor of PI5P4K, which covalently binds to cysteines on a disordered loop in PI5P4Kα/β/γ. It inhibits PI5P4Kα kinase activity with an IC50 of 190 nM and disrupts autophagy by impairing autophagosome clearance and increasing TFEB nuclear localization.