GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3.7 nM. It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model.

GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3.7 nM. It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model.

GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3.7 nM. It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model.

GNE-495 is a potent and selective inhibitor of MAP4K4 with an IC50 value of 3.7 nM. It demonstrates excellent potency and good Pharmacokinetics in in vivo efficacy in a retinal angiogenesis model.

Ammonium tetrathiomolybdate is a potent copper chelator and an effective inorganic H₂S donor. It exhibits H₂S-like cytoprotective effects and is used therapeutically for copper toxicosis, particularly in Wilson’s disease and also in amyotrophic lateral sclerosis (ALS).

Flonoltinib (JAK2/FLT3-IN-1) is a potent and selective dual inhibitor of JAK2 and FLT3, with IC50 of of 0.8, 1.4, and 15 nM against JAK2, JAK2V617F, and FLT3, respectively, in in vitro kinase assays. It also inhibits cell proliferation and induces G2/M cell cycle arrest and apoptosis in Hemophagocytic Lymphohistiocytosis (HLH) patients’ CD8+T cells, CTLL2 cells, […]

Flonoltinib (JAK2/FLT3-IN-1) is a potent and selective dual inhibitor of JAK2 and FLT3, with IC50 of of 0.8, 1.4, and 15 nM against JAK2, JAK2V617F, and FLT3, respectively, in in vitro kinase assays. It also inhibits cell proliferation and induces G2/M cell cycle arrest and apoptosis in Hemophagocytic Lymphohistiocytosis (HLH) patients’ CD8+T cells, CTLL2 cells, […]

Flonoltinib (JAK2/FLT3-IN-1) is a potent and selective dual inhibitor of JAK2 and FLT3, with IC50 of of 0.8, 1.4, and 15 nM against JAK2, JAK2V617F, and FLT3, respectively, in in vitro kinase assays. It also inhibits cell proliferation and induces G2/M cell cycle arrest and apoptosis in Hemophagocytic Lymphohistiocytosis (HLH) patients’ CD8+T cells, CTLL2 cells, […]

Flonoltinib (JAK2/FLT3-IN-1) is a potent and selective dual inhibitor of JAK2 and FLT3, with IC50 of of 0.8, 1.4, and 15 nM against JAK2, JAK2V617F, and FLT3, respectively, in in vitro kinase assays. It also inhibits cell proliferation and induces G2/M cell cycle arrest and apoptosis in Hemophagocytic Lymphohistiocytosis (HLH) patients’ CD8+T cells, CTLL2 cells, […]

XYL-1 is a highly potent inhibitor of PARP7 with and IC50 of 0.6 nM. It could enhance the type-Ⅰinterferon signaling in vitro, and can be a potential candidate for developing cancer immunotherapy agents.