LYMTAC-2 is a lysosomal-targeting chimera (LYMTAC) designed to degrade membrane-associated proteins by leveraging lysosomal membrane proteins (LMPs) like RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with its target protein, such as KRASG12D, and facilitates relocalization to the lysosome, leading to ubiquitin-dependent degradation. It has the potential to study membrane protein regulation and develop […]

Oveporexton (TAK-861) is a potent, orally bioavailable agonist of orexin receptor 2 (OX2R), with an EC50 of 2.5 nM in calcium mobilization assays. It induces dose-dependent membrane depolarization in histaminergic neurons within the mouse tuberomammillary nucleus (TMN) with an EC50 of 31.7 nM.

Oveporexton (TAK-861) is a potent, orally bioavailable agonist of orexin receptor 2 (OX2R), with an EC50 of 2.5 nM in calcium mobilization assays. It induces dose-dependent membrane depolarization in histaminergic neurons within the mouse tuberomammillary nucleus (TMN) with an EC50 of 31.7 nM.

LYMTAC-2 is a lysosomal-targeting chimera (LYMTAC) designed to degrade membrane-associated proteins by leveraging lysosomal membrane proteins (LMPs) like RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with its target protein, such as KRASG12D, and facilitates relocalization to the lysosome, leading to ubiquitin-dependent degradation. It has the potential to study membrane protein regulation and develop […]

LYMTAC-2 is a lysosomal-targeting chimera (LYMTAC) designed to degrade membrane-associated proteins by leveraging lysosomal membrane proteins (LMPs) like RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with its target protein, such as KRASG12D, and facilitates relocalization to the lysosome, leading to ubiquitin-dependent degradation. It has the potential to study membrane protein regulation and develop […]

LYMTAC-2 is a lysosomal-targeting chimera (LYMTAC) designed to degrade membrane-associated proteins by leveraging lysosomal membrane proteins (LMPs) like RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with its target protein, such as KRASG12D, and facilitates relocalization to the lysosome, leading to ubiquitin-dependent degradation. It has the potential to study membrane protein regulation and develop […]

Potrasertib (IMP7068, WEE1-IN-10) is a potent and selective inhibitor of WEE1 Kinase. It displays antitumor activity and is well-tolerated in patients with advanced solid tumors.