Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.

Amelenodor (NX-13) is an orally available, gut-selective molecule that activates the mitochondrial receptor NLRX1 to reduce intestinal inflammation. It promotes oxidative phosphorylation while suppressing proinflammatory pathways like Th1/Th17 differentiation and cytokine production. It has the potential to treat inflammatory bowel disease (IBD).

Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.

Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.

Semustine is a member of the chloroethyl nitrosourea (CENU) family that induces DNA alkylation at the major groove, forming interstrand cross-links between guanine and cytosine bases (dG-dC). It exerts antitumor activity by inducing these DNA cross-links and is used as an antineoplastic alkylating agent for treating Lewis lung carcinoma, leukemia, and metastatic brain tumors.

FOT1 (CN128, CN328) hydrochloride is a potent and orally active hydroxypyridinone iron chelator with potential for treating systemic iron overload and β-thalassemia. It also helps prevent the onset and slows early-stage Parkinson’s disease symptoms by reducing oxidants and toxic intermediates from iron-mediated dopamine oxidation.

NNK is a potent carcinogen formed by nitrosation of nicotine that promotes survival and proliferation of human lung cancer cells. It activates ERK1/2 and PKCα, leading to Bcl2 and c-Myc phosphorylation, which may contribute to lung cancer development and chemoresistance and can be used for lung cancer mice model structure.

FOT1 (CN128, CN328) hydrochloride is a potent and orally active hydroxypyridinone iron chelator with potential for treating systemic iron overload and β-thalassemia. It also helps prevent the onset and slows early-stage Parkinson’s disease symptoms by reducing oxidants and toxic intermediates from iron-mediated dopamine oxidation.

FOT1 (CN128, CN328) hydrochloride is a potent and orally active hydroxypyridinone iron chelator with potential for treating systemic iron overload and β-thalassemia. It also helps prevent the onset and slows early-stage Parkinson’s disease symptoms by reducing oxidants and toxic intermediates from iron-mediated dopamine oxidation.

MYC-IN-3 (Cpd. 37) is an alkynyl-substituted phenylpyrazole derivative and an inhibitor of MYC function by disrupting MYC/MAX interaction with an IC50 of 1.27 μM in PC3 cells and preventing MYC/MAX binding to DNA. It exhibits antiproliferative activity against multiple malignant cell lines and demonstrates enhanced therapeutic efficacy in a mouse allograft model of prostate cancer.