DFP00173 is a selective and potent inhibitor of Aquaporin-3 (AQP3), it inhibits mouse and human AQP3 with an IC50 of ∼0.1 μM–0.4 μM. It demonstrates potential for treating human disorders of water retention.

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits […]

KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein.

PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits […]

PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits […]

PU139 is a potent inhibitor of pan-histone acetyltransferase (HAT) that blocks Gcn5, PCAF, CBP, and p300 with IC50 values of 8.39 μM, 9.74 μM, 2.49 μM, and 5.35 μM, respectively. It significantly impairs Smp14 promoter activity, suggesting that targeting SmGCN5 and SmCBP1 is a novel strategy to control S. mansoni egg development, it also exhibits […]

Propranolol is a non-selective antagonist of β-adrenergic receptors (βAR), with Ki values of 1.8 nM for β1AR and 0.8 nM for β2AR, effectively lowering cAMP levels and activating the MAPK pathway downstream of βARs. It is an effective treatment for infantile hemangiomas (IHs), where it induces antiproliferative and antisurvival effects on hemangioma stem cells (HemSCs).