AkaLumine hydrochloride is a luciferin analogue, with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. Its near-infrared emission peak enables deep tissue imaging and enhances target-detection sensitivity, allowing more accurate, non-invasive bioluminescence imaging at very low concentrations in animal models.

AkaLumine hydrochloride is a luciferin analogue, with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. Its near-infrared emission peak enables deep tissue imaging and enhances target-detection sensitivity, allowing more accurate, non-invasive bioluminescence imaging at very low concentrations in animal models.

AkaLumine hydrochloride is a luciferin analogue, with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. Its near-infrared emission peak enables deep tissue imaging and enhances target-detection sensitivity, allowing more accurate, non-invasive bioluminescence imaging at very low concentrations in animal models.

ZSH‐2208 is a RARγ-selective retinoic acid analogue that exhibits potent anti-tumor effects in oesophageal squamous cell carcinoma (ESCC). It inhibits ESCC tumour-repopulating cells (TRCs) by downregulating TNFAIP3, thereby suppressing proliferation and promoting apoptosis.

ZSH‐2208 is a RARγ-selective retinoic acid analogue that exhibits potent anti-tumor effects in oesophageal squamous cell carcinoma (ESCC). It inhibits ESCC tumour-repopulating cells (TRCs) by downregulating TNFAIP3, thereby suppressing proliferation and promoting apoptosis.

ZSH‐2208 is a RARγ-selective retinoic acid analogue that exhibits potent anti-tumor effects in oesophageal squamous cell carcinoma (ESCC). It inhibits ESCC tumour-repopulating cells (TRCs) by downregulating TNFAIP3, thereby suppressing proliferation and promoting apoptosis.

PRDX1-IN-1 is a celastrol-ligustrazine hybrid and a potent inhibitor of peroxiredoxin 1 (PRDX1) with an IC50 of 0.164 μM. It induces ROS accumulation, inhibits cancer cell growth and metastasis, and exhibits strong antitumor efficacy, making it a promising candidate for lung cancer therapy.

ZSH‐2208 is a RARγ-selective retinoic acid analogue that exhibits potent anti-tumor effects in oesophageal squamous cell carcinoma (ESCC). It inhibits ESCC tumour-repopulating cells (TRCs) by downregulating TNFAIP3, thereby suppressing proliferation and promoting apoptosis.

PRDX1-IN-1 is a celastrol-ligustrazine hybrid and a potent inhibitor of peroxiredoxin 1 (PRDX1) with an IC50 of 0.164 μM. It induces ROS accumulation, inhibits cancer cell growth and metastasis, and exhibits strong antitumor efficacy, making it a promising candidate for lung cancer therapy.

5,6-Dihydroxyindole is an indole derivative crucial for eumelanin biosynthesis, responsible for pigmentation in skin, hair, and eyes. With two hydroxyl groups, it acts as a strong antioxidant, scavenging reactive oxygen species (ROS) and reducing oxidative stress. It oxidizes through the Fenton reaction to form melanin, providing both pigmentation and protection against oxidative damage, especially in […]