Sivelestat sodium (ONO-5046, Sodium sivelestat, LY544349 sodium) is a potent, specific, and intravenously active inhibitor of neutrophil elastase with an IC50 value of 44 nm. It is a useful agent for studying the roles of neutrophil elastase in animal disease models such as emphysema, adult respiratory distress syndrome, septic shock and disseminated intravascular coagulation in […]

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of […]

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of […]

Cetirizine is a second-generation, non-sedating selective antagonist of H1 histamine receptors. It has anti-inflammatory and anti-allergic properties and is used to treat perennial rhinitis and urticaria.

Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) is a potent inhibitor of proton pump. It decreases acid production by inhibiting the H+, K+-ATPase enzyme in gastric parietal cells. Esomeprazole displays pharmacokinetic properties that make it more effective than omeprazole and has the potential for use in research of symptomatic gastroesophageal reflux disease.

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of […]

Agomelatine hydrochloride (S-20098 hydrochloride) is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. It is also a selective antagonist of 5-HT2C receptors with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively. Blockade of […]

Esomeprazole ((S)-Omeprazole, (-)-Omeprazole) is a potent inhibitor of proton pump. It decreases acid production by inhibiting the H+, K+-ATPase enzyme in gastric parietal cells. Esomeprazole displays pharmacokinetic properties that make it more effective than omeprazole and has the potential for use in research of symptomatic gastroesophageal reflux disease.

Miglustat hydrochloride (N-Butyldeoxynojirimycin hydrochloride) is an effective, reversible, and non-toxic iminosugar and an inhibitor of ceramide-specific glucosyl transferase and β-glucosidase 2, with an IC50 of 32 μM and 81 μM, respectively. It is used in the treatment and research of dyslipidosis-related disorders, including GM1 gangliosidosis, Gaucher type I, Tay-Sachs disease, and Niemann-Pick type C disease […]

Pexidartinib Hydrochloride is an oral tyrosine kinase inhibitor of colony-stimulating factor 1 receptor (CSF1R). It significantly reduces macrophage levels in adipose tissue without altering overall myeloid cell counts in mice. It also induces developmental and immunotoxic effects in zebrafish embryos by hyperactivating Wnt signaling.