Pranlukast hemihydrate (ONO-1078 hemihydrate) is an antagonist of cysteinyl leukotriene receptor-1 (CysLT1) that blocks leukotrienes such as LTC4, LTD4, and LTE4, reducing bronchoconstriction and airway inflammation. It also inhibits NF-κB activation, thereby suppressing proinflammatory cytokine production (e.g., IL-6, IL-1, TNF-α) in monocytes/macrophages and T cells, contributing to its immunomodulatory effects.

(S)-Terazosin is a potent and selective antagonist of α-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. It also has high-affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 729 nM, 3.5 nM and 46.4 nM, respectively. It may prove to be a useful probe […]

(S)-Terazosin is a potent and selective antagonist of α-adrenoceptor with Ki values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, α1b and α1d-adrenoceptor, respectively. It also has high-affinity for α2a, α2B and α2c-adrenoceptor with Ki values of 729 nM, 3.5 nM and 46.4 nM, respectively. It may prove to be a useful probe […]

Phentolamine hydrochloride is a potent, selective, and orally active antagonist of α1 and α2 adrenergic receptors , with pKi values of 8.8, 8.0, and 8.3 for the human α2A, α2B, and α2C adrenergic receptors, respectively. It also shows binding affinities for the α1-adrenoceptor subtypes, exhibiting Ki values of 6.1 nM for cloned α1A/D, 39.8 nM […]

Pranlukast hemihydrate (ONO-1078 hemihydrate) is an antagonist of cysteinyl leukotriene receptor-1 (CysLT1) that blocks leukotrienes such as LTC4, LTD4, and LTE4, reducing bronchoconstriction and airway inflammation. It also inhibits NF-κB activation, thereby suppressing proinflammatory cytokine production (e.g., IL-6, IL-1, TNF-α) in monocytes/macrophages and T cells, contributing to its immunomodulatory effects.

Phentolamine hydrochloride is a potent, selective, and orally active antagonist of α1 and α2 adrenergic receptors , with pKi values of 8.8, 8.0, and 8.3 for the human α2A, α2B, and α2C adrenergic receptors, respectively. It also shows binding affinities for the α1-adrenoceptor subtypes, exhibiting Ki values of 6.1 nM for cloned α1A/D, 39.8 nM […]

Phentolamine hydrochloride is a potent, selective, and orally active antagonist of α1 and α2 adrenergic receptors , with pKi values of 8.8, 8.0, and 8.3 for the human α2A, α2B, and α2C adrenergic receptors, respectively. It also shows binding affinities for the α1-adrenoceptor subtypes, exhibiting Ki values of 6.1 nM for cloned α1A/D, 39.8 nM […]

2′-C-Methylcytidine (NM107) is a potent and selective inhibitor of Chronic hepatitis C virus (HCV) NS5B polymerase with an EC50 of 1.85 μM in wild-type replicon cells. It also effectively inhibits foot-and-mouth disease virus(FMDV) replication with an EC50 of 6.4 μM. Therefore it is a potent antiviral that targets both viral and host factors, making it […]

Phentolamine hydrochloride is a potent, selective, and orally active antagonist of α1 and α2 adrenergic receptors , with pKi values of 8.8, 8.0, and 8.3 for the human α2A, α2B, and α2C adrenergic receptors, respectively. It also shows binding affinities for the α1-adrenoceptor subtypes, exhibiting Ki values of 6.1 nM for cloned α1A/D, 39.8 nM […]

2′-C-Methylcytidine (NM107) is a potent and selective inhibitor of Chronic hepatitis C virus (HCV) NS5B polymerase with an EC50 of 1.85 μM in wild-type replicon cells. It also effectively inhibits foot-and-mouth disease virus(FMDV) replication with an EC50 of 6.4 μM. Therefore it is a potent antiviral that targets both viral and host factors, making it […]