SD-2301 is a potent and selective PROTAC-based STAT3 degrader that targets the VHL–cullin 2 complex, enhancing dendritic cell function and anti-tumor immunity. It synergizes with anti-PD-L1 therapy to robustly suppress tumor growth in vivo.

CORM-401 is a water-soluble Carbon monoxide-releasing molecule that exhibits antioxidant and cytoprotective effects under oxidative stress conditions, including TNF-α/CHX and H₂O₂-induced damage. It induces nitric oxide production, activates the pentose phosphate pathway, and triggers distinct calcium signaling patterns, contributing to the regulation of endothelial function.

CORM-401 is a water-soluble Carbon monoxide-releasing molecule that exhibits antioxidant and cytoprotective effects under oxidative stress conditions, including TNF-α/CHX and H₂O₂-induced damage. It induces nitric oxide production, activates the pentose phosphate pathway, and triggers distinct calcium signaling patterns, contributing to the regulation of endothelial function.

CORM-401 is a water-soluble Carbon monoxide-releasing molecule that exhibits antioxidant and cytoprotective effects under oxidative stress conditions, including TNF-α/CHX and H₂O₂-induced damage. It induces nitric oxide production, activates the pentose phosphate pathway, and triggers distinct calcium signaling patterns, contributing to the regulation of endothelial function.

CORM-401 is a water-soluble Carbon monoxide-releasing molecule that exhibits antioxidant and cytoprotective effects under oxidative stress conditions, including TNF-α/CHX and H₂O₂-induced damage. It induces nitric oxide production, activates the pentose phosphate pathway, and triggers distinct calcium signaling patterns, contributing to the regulation of endothelial function.

Sulindac sulfide is a potent, reversible and noncompetitive inhibitor of γ42-secretase with an IC50 of 20.2 μM. It preferentially reduces Aβ42 generation, inhibits Aβ40 and Notch intracellular domain production, and can be used in Alzheimer’s disease research.

Sulindac sulfide is a potent, reversible and noncompetitive inhibitor of γ42-secretase with an IC50 of 20.2 μM. It preferentially reduces Aβ42 generation, inhibits Aβ40 and Notch intracellular domain production, and can be used in Alzheimer’s disease research.

Sulindac sulfide is a potent, reversible and noncompetitive inhibitor of γ42-secretase with an IC50 of 20.2 μM. It preferentially reduces Aβ42 generation, inhibits Aβ40 and Notch intracellular domain production, and can be used in Alzheimer’s disease research.

Sulindac sulfide is a potent, reversible and noncompetitive inhibitor of γ42-secretase with an IC50 of 20.2 μM. It preferentially reduces Aβ42 generation, inhibits Aβ40 and Notch intracellular domain production, and can be used in Alzheimer’s disease research.

VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinase 1 (VRK1) with an IC50 of approximately 150 nM. It also facilitates H4 deacetylation (reducing H4K16 acetylation) and promotes the accumulation of DNA strand breaks while preventing progression of the DNA repair process.