Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.

Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

DiBAC4(3) is a voltage-sensitive fluorescent dye (λex=490 nm, λem=505 nm).

CY7-SE is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the […]

UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).

Novobiocin (Albamycin, Cathomycin) is a potent, orally active antibiotic and an inhibitor of DNA gyrase andtopoisomerase II, and also an antagonist of heat shock protein 90 (Hsp90). It shows potential for treating β-lactam-resistant pneumococcal infections and sensitizing brain tumors to DNA cross-linking anticancer agents.

2-Theoyltrifluoroacetone is a chelating agent and mitochondrial electron transfer chain inhibitor, with a IC50 value of 51.5 μM. 2-Thermoyltrifluoroacetone can chelate with various metal ions and has cytotoxicity and anti-tumor activity, which is expected to play an important role in the treatment of mitochondrial dysfunction related diseases[1][2][3].

PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride), a reversible tryptophan hydroxylase inhibitor, is a serotonin (5-HT) synthesis inhibitor. PCPA methyl ester hydrochloride crosses the blood brain barrier and reduces 5-HT central availability.

N-Acetyl-L-cysteine ethyl ester is a lipophilic, cell-permeable cysteine derivative that acts as a mucolytic agent, paracetamol antidote, and GSH-related antioxidant, protecting against hydroperoxide-induced oxidative damage. It efficiently enters cells, releases N-acetyl-L-cysteine (NAC) and cysteine, and increases circulating hydrogen sulfide (H₂S), making it a promising oral H₂S donor.

Olverembatinib (GZD824, HQP1351) is an orally bioavailable inhibitor of pan-Bcr-Abl. It effectively inhibits a wide range of Bcr-Abl mutants, with IC50 of 0.34 nM and 0.68 nM for native Bcr-Abl and the Bcr-AblT315I mutant, respectively. It also induces tumor regression in mouse xenograft models.