C6 Ceramide (C6-Cer, N-Hexanoylsphingosine) is a short-chain, cell-permeable ceramide with anticancer properties, including cell cycle arrest, apoptosis, and tumor growth inhibition. It enhances chemotherapy efficacy in drug-resistant cancers by promoting miR-29b expression, which suppresses endothelial cell proliferation, migration, and angiogenesis through the Akt signaling pathway. In combination with Trichostatin A, C6 Ceramide disrupts the HDAC6/PP1/tubulin […]

BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with an IC50s of ~5 μM for actin- and Ca2+-stimulated myosin S1 ATPase. BTS specifically inhibits the contraction of fast skeletal muscle fibers.

Ensitrelvir (S-217622) is an oral, non-covalent, non-peptidic inhibitor of the SARS-CoV-2 3CL protease, with an IC50 of 13 nM. It also exhibits antiviral activity in vitro and is a potential oral agent for treating COVID-19.

Dihomo-γ-linolenic acid (DGLA, all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 polyunsaturated fatty acid (PUFA) derived in vivo from linolenic acid. It exhibits antitumor, anti-inflammatory, and antiproliferative effects, making it a promising candidate for the prevention and treatment of hyperplasia and proliferative diseases, especially for cancers.

Purpurin-18 is a chlorophyll-derived dihydroporphyrin, serves as a key precursor for photosensitizers like purpurinimides, which absorb light in the 700–850 nm range. It demonstrate potent photodynamic anti-tumor activity and generates ROS, disrupting mitochondrial membrane potential and inducing apoptosis against triple-negative breast cancer both in vitro and in vivo.

N²,N²-Dimethylguanosine (m 2 2 G) is a key post-transcriptional modification found in tRNAs, where two methyl groups are added to the N² position of guanosine. This modification is essential for improving tRNA structural stability and functionality, particularly at positions like G26, which are critical for ensuring the correct conformation for efficient translation. Enzymes such as […]

DSRM-3716 (5-Iodoisoquinoline) is a potent and selective SARM1 NADase inhibitor with an IC50 of 75 nM. DSRM-3716 is selective against other NAD+-processing enzymes, receptors, and transporters. DSRM-3716 provides robust axon protection.

BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.

Sulfo-NHS-LC-Biotin sodium is an amine-reactive biotinylation reagent that can be used for antibody labeling.

Rigosertib (ON-01910) is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition the PI3 kinase/Akt pathway, promots the phosphorylation of histone H2AX and induces G2/M arrest in cell cycle. Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM.