Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide) is a metabolite of kaempferol that can be taken orally and has anti-inflammatory properties. Kaempferol 3-O-β-D-glucuronide can activate AKT/GSK3β phosphorylation and improve glucose metabolism.

Deoxycorticosterone is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as an aldosterone precursor. Deoxycorticosterone is an agonist for O. mykiss mineralocorticoid receptor (rtMR) transcription with EC50 of 0.16 nM. Deoxycorticosterone could acts as an immune stimulator in fish.

Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC50 of 50 μM.

Triapine (3-AP; PAN-811) is a potent inhibitor of the M2 subunit of ribonucleotide reductase (RR), and is a potent radiosensitizer.

Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation […]

Ellipticine (NSC 71795) is a potent antitumor alkaloid that inhibits the activity of DNA topoisomerase II. It acts by intercalating into DNA, causing DNA damage and inducing cytotoxicity. It also can disrupt mitochondrial oxidative phosphorylation and exhibits potential antineoplastic effects.

Hypotaurine (2-Aminoethanesulfinic acid) is a sulfur-containing amino acid and a precursor in the biosynthesis of taurine. It exhibits antioxidant properties, capable of scavenging free radicals and protecting cells from oxidative stress and may offer therapeutic advantages in certain neurological conditions.

5-TAMRA-SE is an amine-reactive fluorescent agent, and its conjugate produces bright, pH-insensitive orange-red fluorescence with good photostability.

Insulin(cattle) is a two-chain polypeptide hormone produced by pancreatic β cells and commonly used as a growth supplement in cell culture. Its native structure is crucial for receptor interaction, regulating glucose homeostasis, while its stable hexameric form or analogs are used for storage and injection.

BS-181 is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY-30237). BS-181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880, 3000 and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS-181 inhibits a panel of cancer cells growth (IC50=11.5 μM-37.3 μM) and induces cell apoptosis. BS-181 has […]