5(6)-TAMRA is a fluorescent dye molecule widely used as a label for peptides and proteins.

n-Octyl β-D-glucopyranoside is a non-ionic glycolipid widely used in biochemical applications. It forms stable, hydrated prolate ellipsoid micelles and can inhibits cavitation-induced cell lysis in vitro.

Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit […]

5-ROX (5-Carboxy-X-rhodamine) is a rhodamine dye that exhibits strong fluorescence in aqueous buffer with an excitation maximum (λₑₓᵢₜ) at 580 nm (ε = 3.6 × 10⁴ M⁻¹ cm⁻¹) and an emission maximum (λₑₘᵢₜ) at 604 nm (ϕ = 0.94). It is highly photostable and widely used for biomolecular labeling and fluorescence-based detection.

Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α).

D-α-tocopherol succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E that significantly reduces the cisplatin-induced increase of ROS and decreases cellular necrosis and late apoptosis, thereby inhibiting cisplatin-induced cytotoxicity in HEIOC1 cells. It also exhibits an anti-apoptotic effect.

6-FAM (6-Carboxyfluorescein) is an isomer of carboxyfluorescein and is mainly used for sequencing and labeling of nucleic acids.

PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis.

KAT8-IN-1 is an inhibitor of lysine acetyltransferase 8 (KAT8)> with IC50 values of 141 μM, 221 μM and 106 μM for KAT8, KAT2B, KAT3B respectively. By inhibiting histone acetyltransferases (HATs), it helps investigate their role in disease and holds potential as a therapeutic agent for cancer and inflammatory conditions.

Ciglitazone is a potent and selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells.