BQ-788 sodium salt is a potent and selective ETB receptor antagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells.

Necrostatin-2 is a potent inhibitor of necroptosis with an EC50 of 50 nM in FADD-deficient Jurkat T cells treated with TNF-α.

ATN-224 is a second-generation tetrathiomolybdate analogue and an orally active inhibitor of Cu2+/Zn2+-superoxide dismutase 1 (SOD1) with an IC50 of 17.5 nM. It inhibits angiogenesis and tumor growth and can be used in advanced solid and advanced hematologic malignancies research.

AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) […]

2′,5′-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2′,5′-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart.

G-418 (Geneticin, Antibiotic G-418) is an aminoglycoside antibiotic originally isolated from Micromonospora rhodorangea. It functions by binding to the ribosomal subunit, thereby inhibiting translational elongation and disrupting protein synthesis in both prokaryotic and eukaryotic cells, thus impairing cell growth and viability.

MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM.

Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo.

CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.