tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of  0.33 µM.

T807 a novel tau positron emission tomography (PET) tracer.

α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM.

Cytidine 5′-triphosphate (Cytidine triphosphate; 5′-CTP) is a nucleoside triphosphate involved in the synthesis of nucleotides, nucleic acids, and lipids. It is produced from uridine 5′-triphosphate (UTP) by the enzyme CTP synthase. In Toxoplasma gondii, cytidine 5′-triphosphate is essential for pyrimidine biosynthesis, thereby supporting parasite growth and survival.

ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy […]

10,12-Tricosadiynoic acid is a highly specific, selective, high-affinity, and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1), it enhances hepatic mitochondrial FAO via the SIRT1-AMPK pathway and PPARα activation. It also reduces liver lipids, ROS accumulation, and insulin resistance, indicating its potential for treating metabolic diseases such as fatty liver, hypertriglyceridemia, and possibly diabetes.

R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.

Retaspimycin is a potent inhibitor of Hsp90, with EC50s of 119 nM for both Hsp90 and Grp9.

(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC50 of 126 nM.

2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone, with a pKa of 10.81.