Prinaberel (ERB-041) is a potent and selective estrogen receptor (ER) β agonist with IC50s of 5.4, 3.1 and 3.7 nM for human, rat and mouse ERβ, respectively. Prinaberel displays >200-fold selectivity for ERβ over ERα. Prinaberel is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Prinaberel induces ovarian cancer […]

AP1867 is a synthetic FKBP12F36V-directed ligand.

Anguizole is a small molecule inhibitor of HCV replication and alters NS4B’s subcellular distribution.IC50 Value: Target: HCV

TFLLR-NH2 (TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM.

Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(

Azimilide(NE-10064) is a class III antiarrhythmic compound, inhibits I(Ks) and I(Kr) in guinea-pig cardiac myocytes and I(Ks) (minK) channels expressed in Xenopus oocytes.IC50 value:Target: in vitro: Azimilide blocked HERG channels at 0.1 and 1 Hz with IC50s of 1.4 microM and 5.2 microM respectively. Azimilide blockade of HERG channels expressed in Xenopus oocytes and I(Kr) […]

Bromperidol (R-11333) possesses antipsychotic activity, with a high affinity for central dopamine receptors D2. Bromperidol can kill Mycobacteria in a synergistic manner with Spectinomycin.

Cevipabulin (TTI-237) is an oral, microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin, with an IC50 of 18-40 nM for cytotoxicity in human tumor cell line.

O-1602 is a potent agonist of G-protein coupled receptor 55 (GPR55). It exhibits anxiolytic and antidepressant effects by preventing Methamphetamine (METH)-induced hippocampal neurogenic damage and neuroinflammation, as well as stress from chronic social defeat.

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).