MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a Ki value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis.

Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease.Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression.

Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria.

Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively.

Fipexide, a parachloro-phenossiacetic acid derivative, is an orally active nootropic that improves cognitive performance through dopaminergic neurotransmission. It reduces striatal adenylate cyclase activity, enhancing memory and cognitive function. It also acts as a chemical inducer in callus formation, shoot regeneration, and Agrobacterium infection.

6-FITC (6-Fluorescein Isothiocyanate) is a derivative of fluorescein used in wide-ranging applications including flow cytometry.

Cyclo(RADfK) is a selective Integrin αvβ3 ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

ACY-957 is a selective chemical inhibitor of HDAC1 and HDAC2 with an IC50 values of 7 nM, 18 nM against HDAC1/2 respectively. It induces hemoglobin protein (HbF) in primary erythroid progenitor cells, including those from sickle cell patients, offering a promising approach for treating sickle cell disease (SCD) and β-thalassemia.

Aurothioglucose (Gold thioglucose), containing monovalent gold ion, is a potent active-site inhibitor of TrxR1 (thioredoxin reductase 1), with an IC50 of 65 nM. Aurothioglucose inhibits the DNA binding of NF-κB in vitro. Aurothioglucose shows anti-HIV and anti-rheumatic activities.

Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a Kd of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities. Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide […]