Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression.

Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant […]

ML218 is a potent, selective, and orally active inhibitor of T-type Ca²⁺ channels (Cav3.1, Cav3.2, and Cav3.3), with IC50 of 310 nM for Cav3.2 and 270 nM for Cav3.3. It effectively suppresses burst activity in subthalamic nucleus (STN) neurons.

Oxazine 1 perchlorate is a symmetric cationic dye (λex=653 nm, λem=666 nm).

Sagittatoside B is a natural compound isolated from traditional Chinese herb Yinyanghuo (Herba Epimdii).

Sagittatoside A is a natural compound isolated from traditional Chinese herb Yinyanghuo (Herba Epimdii).

Chromafenozide (ANS118) is a diacylhydrazine class of insecticides that specifically targets Lepidoptera species. It acts as a potent and selective partial agonist of ecdysone receptor in Sf9 cells.

GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.

Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity.

Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist.