The 5-Ph-IAA is a bumped-IAA analogue, that establishes the auxin-inducible degron 2 (AID2) system with the OsTIR1(F74G) mutant, enabling precise, rapid degradation with 670-fold lower ligand concentration. It induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, exhibiting significant tumor suppression properties.

TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined.

Hoechst 33342 trihydrochloride (Bisbenzimide ethoxide trihydrochloride, HOE 33342 trihydrochloride) is a bis-benzimide fluorescent dye that specifically binds to AT-rich sequences in the minor groove of double-stranded DNA. When exposed to UV light, it emits bright fluorescence at Hoechst Red (630–650 nm) and Hoechst Blue (405–450 nm) wavelengths. This dye is used to determine cell cycle […]

Streptomycin (Agrept, Agrimycin, Streptomycin A) is an aminoglycoside antibiotic isolated from Streptomyces griseus and used in tuberculosis (TB) research due to its activity against Mycobacterium tuberculosis. It is also a bactericidal agent useful for studying various bacterial infections.

AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay.

Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects.

NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.

C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B.

SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments.

Substance P (Neurokinin P) is an 11-amino-acid neuropeptide and an agonist for the neurokinin-1 receptor (NK1R), binding with high affinity to regulate pain, anxiety, and stress responses. It is present in the CNS and PNS, playing a key role in neurotransmission, neuromodulation, and wound healing research.