Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma.

E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer’s disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.

TG6-10-1 is a selective, brain-penetrant antagonist of EP2 receptor with nanomolar potency. It reduces delayed mortality, neuroinflammation, and hippocampal neurodegeneration after status epilepticus (SE) in mice. TG6-10-1 provides neuroprotection via anti-inflammatory mechanisms without direct anticonvulsant effects.

DiD is a long-chain carbocyanine dye. Carbocyanine dyes are widely used as Di to label cells, organelles, liposomes, viruses and lipoproteins.

Ro 48-8071 is an inhibitor of OSC (Oxidosqualene cyclase) with IC50 of appr 6.5 nM.

Guanosine-5′-triphosphate disodium salt (5′-GTP disodium salt) is an intracellular signaling molecule, playing a key role in G protein-coupled receptor signaling and activating effector enzymes. It also enhances myogenic cell differentiation by upregulating miR-133a/b and myogenic regulatory factors, while promoting the release of guanosine-rich exosomes from human myogenic precursor cells. It may hold promise for research […]

Rat CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) and a highly selective antagonist of CGRP receptor. It exhibits anti-nociceptive effects and is effective in abolishing mechanical and thermal allodynia produced by spinal hemisection and may play a role in chronic central neuropathic pain.

L-Asparaginase(L-ASNase) is a deamidating enzyme that hydrolyzes L-asparagine and L-glutamine, depleting L-asparagine in the blood and bone marrow. It exhibits anti-leukemic effects by inhibiting RNA and DNA synthesis, leading to blastic cell apoptosis, and is used in acute lymphoblastic leukemia (ALL) research and treatment.

L-Leucyl-L-Leucine methyl ester hydrobromide (Leu-Leu-ome hydrobromide) is a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates cytotoxic lymphocytes, including natural killer (NK) cells, from mixed lymphocyte populations. It also induces stress in the endolysosomal pathway, highlighting its potential impact on immune cell regulation.

DMG-PEG 2000 is used?for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the?lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.