CP2
CP2 is a cyclic peptide that inhibits the JmjC histone demethylases KDM4 with IC50 values of 42 nM and 29 nM for KDM4A and KDM4C, respectively.
| Trivial name | N/A |
| Catalog Number | S8601 |
| Molecular Formula | C92H120N24O26S |
| Inchi | InChI=1S/C92H120N24O26S/c1-44(2)74-87(138)109-62(31-47-17-23-52(120)24-18-47)81(132)108-66(36-71(93)124)85(136)114-75(45(3)118)88(139)105-60(16-10-30-99-92(96)97)80(131)110-68(41-117)78(129)102-40-72( 125)103-64(34-50-38-100-57-13-7-5-11-55(50)57)82(133)104-59(15-9-29-98-91(94)95)79(130)107-65(35-51-39-101-58-14-8-6-12-56(51)58)83(134)106-63(32-48-19-25-53(121)26-20-48)84(135)113-76(46(4)119)89(140 )111-69(90(141)142)42-143-43-70(123)77(128)61(37-73(126)127)115-116-67(86(137)112-74)33-49-21-27-54(122)28-22-49/h5-8,11-14,17-28,38-39,44-46,59-69,74-76,100-101,115-122H,9-10,15-16,29-37,40-43H2,1-4H 3,(H2,93,124)(H,102,129)(H,103,125)(H,104,133)(H,105,139)(H,106,134)(H,107,130)(H,108,132)(H,109,138)(H,110,131)(H,111,140)(H,112,137)(H,113,135)(H,114,136)(H,126,127)(H,141,142)(H4,94,95,98)(H4,96,97 ,99)/t45-,46-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,74-,75-,76-/m0/s1 |
| Inchi Key | LHXZPGSWUKPLEX-BAKGJXLISA-N |
| SMILES | CC(C)C1NC(=O)C(CC2=CC=C(O)C=C2)NNC(CC(O)=O)C(=O)C(=O)CSCC(NC(=O)C(NC(=O)C(CC3=CC=C(O)C=C3)NC(=O)C(CC4=C[NH]C5=C4C=CC=C5)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC6=C[NH]C7=C6C=CC=C7)NC(=O)CNC(=O)C(CO)NC(=O)C(CCCNC |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/cp2.html |
| Additional Information | https://file.selleck.cn/downloads/struct/cp2-chemical-structure-s8601.gif |