ZK53 | MedChemExpress (MCE)
ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37?μM for α-casein hydrolysis by HsClpP). ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model[1].
Trivial name | ZK53 |
Catalog Number | HY-149677 |
Research Area | Cancer |
Purity | 98.94% |
SMILES | FC1=CC(F)=CC(CN2CCN(C(NCC3=CC=C(Br)C=C3)=O)CC2)=C1 |
PubChem Chemical Structure ID | 168499425 |
Size | 25 mg |
Supplier Page | https://www.medchemexpress.com/zk53.html |