Vardenafil-d5 hydrochloride | MedChemExpress (MCE)
Vardenafil-d5 hydrochloride is deuterated labeled Vardenafil hydrochloride (HY-B0442A). Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows inhibitory towards PDE1, PDE6 with IC50s of 180 nM, and 11 nM, while IC50s are >1000 nM for PDE3 and PDE4[1]. Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels[2]. Vardenafil hydrochloride can be used for the research of erectile dysfunction, hepatitis, diabetes[1]-[6].
| Trivial name | Vardenafil-d5 hydrochloride |
| Catalog Number | HY-B0442AS |
| Research Area | Metabolic Disease; Inflammation/Immunology; Endocrinology |
| Purity | ≥98.0% |
| SMILES | CC1=C2N(NC(C3=CC(S(=O)(N4CCN(CC4)C([2H])(C([2H])([2H])[2H])[2H])=O)=CC=C3OCC)=NC2=O)C(CCC)=N1.Cl |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/vardenafil-d5-hydrochloride.html |