rel-PROTAC PARP1 degrader | MedChemExpress (MCE)
rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.
| Trivial name | rel-PROTAC PARP1 degrader |
| Catalog Number | HY-114324A |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | O=C(CN(C(N1C(C2=CC=C(OC)C=C2OC(C)C)=N[C@H](C3=CC=C(Cl)C=C3)[C@@H]1C4=CC=C(Cl)C=C4)=O)CC5)N5CC(NCCOCCOCCOCCOCCN6N=NC(C7=CC=C(N8N=C(C(C(N)=O)=CC=C9)C9=C8)C=C7)=C6)=O.[rel-] |
| Size | 25 mg |
| Supplier Page | https://www.medchemexpress.com/rel-protac-parp1-degrader.html |