NSCLC-IN-1 | MedChemExpress (MCE)
NSCLC-IN-1 (Compound A10-2) induces mitophagy and ferroptosis through targeting transmembrane BAX inhibitor motif containing 6 (TMBIM6). NSCLC-IN-1 induces mitochondrial Ca2+ imbalance, leading to mitochondrial damage. NSCLC-IN-1 reduces intracellular glutathione (GSH), increases the accumulation of lipid peroxides (LPO) and malondialdehyde (MDA) content. NSCLC-IN-1 is a potent anti-NSCLC agent[1].
| Trivial name | NSCLC-IN-1 |
| Catalog Number | HY-161388 |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | O=C(O[C@H]1C(C)=C[C@]23[C@]1(O)[C@H](O)C(COC(C4=CC=C([N+]([O-])=O)C=C4)=O)=CC(C3=O)([H])[C@@]5([H])[C@@](C5(C)C)(OC(CCCCCCCCCCC)=O)C[C@H]2C)C6=CC=C([N+]([O-])=O)C=C6 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/nsclc-in-1.html |