MAPK-IN-2 | MedChemExpress (MCE)
MAPK-IN-2 (compound 3h) is a potent MAPK inhibitor with antineoplastic activity. MAPK-IN-2 inhibits cancer cell proliferation among serval cancer cell lines, and suppresses MAPK pathway with potant efficacy (EGFRWT IC50=281 nM, c-MET IC50=205 nM, B-RAFWT IC50=112 nM, and CDK4/6 IC50=95 and 184 nM, respectively). MAPK-IN-2 even shows a remarkable potency against mutated EGFR and B-RAF (EGFRT790M IC50=69 nM and B-RAFV600E IC50=83 nM)[1].
Trivial name | MAPK-IN-2 |
Catalog Number | HY-155736 |
Research Area | Cancer |
Purity | ≥98.00% |
SMILES | O=C1C(C#N)=C(C2=CC=C(Cl)C=C2Cl)C=C(C3=CNC4=C3C=CC=C4)N1 |
PubChem Chemical Structure ID | 168510404 |
Size | 1 mg |
Supplier Page | https://www.medchemexpress.com/mapk-in-2.html |