LYP-IN-4 | MedChemExpress (MCE)
LYP-IN-4 (compound D14) is a reversible and selective inhibitor of lymphotyrosine phosphatase (LYP) (Ki=1.34 μM, IC50=3.52μM). LYP-IN-4 inhibits LYP to regulate TCR signaling, up-regulates PD-1/PD-L1 expression, and enhance anti-tumor immunity. LYP-IN-4 activates T cells and inhibits M2 macrophage polarization, inhibits tumor growth in MC38 isogenic mouse models.
| Trivial name | LYP-IN-4 |
| Catalog Number | HY-155848 |
| Research Area | Cancer |
| Purity | 98.09% |
| SMILES | O=C(O)C1=CC2=CC(N(S(=O)(C(C=C3)=CC(Cl)=C3[N+]([O-])=O)=O)CC4=CC=C(C=C4)C5=CC=C(C=C5)OC)=CC=C2O1 |
| PubChem Chemical Structure ID | 168510430 |
| Size | 5 mg |
| Supplier Page | https://www.medchemexpress.com/lyp-in-4.html |