LYP-IN-3 | MedChemExpress (MCE)
LYP-IN-3 (compound D34) is a selective inhibitor of Lymphoid-tyrosine phosphatase (LYP) (Ki=0.93 μM), and regulates T-cell receptor (TCR) signaling pathway in tumor progress. LYP-IN-3 activates T-cell and inhibits M2 macrophage polarization, but upregulates PD-1/PD-L1 expression. LYP-IN-3 can be leveraged with PD-1/PD-L1 inhibitor, for futher cancer immunotherapy[1].
| Trivial name | LYP-IN-3 |
| Catalog Number | HY-155847 |
| Research Area | Cancer |
| Purity | 99.80% |
| SMILES | O=C(C1=CC2=CC(N(CC3=CC=C(OCC4=CC=CC=C4)C=C3)S(=O)(C5=CC=C(C6=CC=CC=C6)C=C5)=O)=CC=C2O1)O |
| PubChem Chemical Structure ID | 168510429 |
| Size | 5 mg |
| Supplier Page | https://www.medchemexpress.com/lyp-in-3.html |