LHF418 | MedChemExpress (MCE)

LHF418 is an effective SOS1 PROTAC degrader with a DC₅₀ value of 209.4 nM in A549 cells. LHF418 can effectively inhibit RAS signaling and colony formation in KRAS-driven cancer cells. (Structural note: (Blue: Cereblon ligand (HY-A0003), Black: linker; Pink: SOS1 binder SOS1 Ligand intermediate-3 (HY-161452))^[1].

Price Not Available 1 mg LHF418 | MedChemExpress (MCE) Supplier Page

Trivial name	LHF418
Catalog Number	HY-161450
Research Area	Cancer
Purity	≥98.0%
SMILES	NC1=CC([C@@H](C)CC2=NC(C)=NC3=C2C=C(O[C@@H]4CN(C(CCCCCCCC(NC5=C6C(C(N(C7CCC(NC7=O)=O)C6)=O)=CC=C5)=O)=O)CC4)C(OC)=C3)=CC(C(F)(F)F)=C1
Size	1 mg
Supplier Page	https://www.medchemexpress.com/lhf418.html