JPS016 TFA | MedChemExpress (MCE)
JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
| Trivial name | JPS016 TFA |
| Catalog Number | HY-145816A |
| Research Area | Cancer |
| Purity | 98.70% |
| SMILES | OC(C(F)(F)F)=O.O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCCCCCCCCOCC(NC(C=C4)=CC=C4C(NC(C=CC=C5)=C5N)=O)=O)=O |
| PubChem Chemical Structure ID | 168510230 |
| Size | 50 mg |
| Supplier Page | https://www.medchemexpress.com/jps016-tfa.html |