JPS014 TFA | MedChemExpress (MCE)
JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS014 TFA degrades class I histone deacetylase (HDAC). JPS014 TFA is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].
| Trivial name | JPS014 TFA |
| Catalog Number | HY-145815A |
| Research Area | Cancer |
| Purity | 98.40% |
| SMILES | O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCCCCCCCOCC(NC4=CC=C(C(NC5=CC=CC=C5N)=O)C=C4)=O.OC(C(F)(F)F)=O |
| PubChem Chemical Structure ID | 168510229 |
| Size | 100 mg |
| Supplier Page | https://www.medchemexpress.com/jps014-tfa.html |