β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE | MedChemExpress (MCE)
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC50 value of 5.7 nM – 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects[1].
| Trivial name | β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE |
| Catalog Number | HY-155313 |
| Research Area | Cancer |
| Purity | ≥98.00% |
| SMILES | CN(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](OC(N(CCN(C)C(OCC2=CC([N+]([O-])=O)=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O3)C=C2)=O)C)=O)C4=CC=CC=C4)=O)CCC1)=O)=O)=O |
| PubChem Chemical Structure ID | 169450088 |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/β-glucuronide-nb-bis-n-me-methyl-ester-mmae.html |