ERK1/2 inhibitor 10 | MedChemExpress (MCE)
ERK1/2 inhibitor 10 (Compound 36c) is a potent ERK1/2 inhibitor (IC50: 0.11/0.08 nM respectively). ERK1/2 inhibitor 10 inhibits ERK1/2 and blocks the phosphorylation expression of their downstream substrates p90RSK and c-Myc. ERK1/2 inhibitor 10 induces cell apoptosis and incomplete autophagy-related cell death. ERK1/2 inhibitor 10 shows potent antitumor efficacy against triple-negative breast cancer and colorectal cancer models harboring BRAF and RAS mutations[1].
| Trivial name | ERK1/2 inhibitor 10 |
| Catalog Number | HY-162460 |
| Research Area | Cancer |
| Purity | ≥98.0% |
| SMILES | O=C(C1=CC(C2=NC(NC3=CC=NC(C)=C3)=NC=C2Cl)=CS1)N[C@@H](C4=CC=CC=C4)CO |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/erk1-2-inhibitor-10.html |