VLX600
VLX600 is a small molecule which is cytotoxic to quiescent cells in colon cancer cells with an IC₅₀ of 1-10 μM. VLX600 decreases mitochondrial oxidative phosphorylation and shows enhanced cytotoxic activity under conditions of nutrient starvation. It inhibits growth of colon cancer xenografts with minimal systemic toxicity in mice.
| Trivial name | VLX600 (RE1054) |
| Catalog Number | RE1054 |
| Alternative Name(s) | 6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine; 6-Methyl-3-((2E)-2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-(1,2,4)triazino(5,6-b)indole; Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino(5,6-b)indol-3-yl)hydrazone |
| Research Area | Other/Reagents |
| Molecular Formula | C₁₇H₁₅N₇ |
| Inchi | InChI=1S/C17H15N7/c1-10-6-5-7-12-14(10)19-16-15(12)22-24-17(20-16)23-21-11(2)13-8-3-4-9-18-13/h3-9H,1-2H3,(H2,19,20,23,24)/b21-11+ |
| Size | 10mg |
| Supplier Page | https://www.mitochondriasci.com/vlx600-item-625.html |
| Additional Information | Appearance:A crystalline solid |