Rotenone
A broad spectrum insecticide that is cell-permeable and brain-permeable. Acts as a mitochondrial electron transport chain inhibitor (IC₅₀ = 1.7 – 2.2 μM at complex I). Inhibits NADH oxidation by cardiac sarcoplasmic reticulum (IC₅₀ = 3.4 nM). Neurotoxic agent that has also been used successfully to reproduce Parkinsons-like characteristics in in-vitro slice culture models.
| Trivial name | Rotenone (RE1057) |
| Catalog Number | RE1057 |
| Alternative Name(s) | (2R,6aS,12aS)-1,2,12,12a-Tetrahydro-8,9-dimethoxy-2-(1-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-][1]benzopyran-6(6aH)-one |
| Research Area | Other/Reagents |
| Molecular Formula | C₂₃H₂₂O₆ |
| Inchi | InChI=1S/C23H22O6/c1-11(2)16-8-14-15(28-16)6-5-12-22(24)21-13-7-18(25-3)19(26-4)9-17(13)27-10-20(21)29-23(12)14/h5-7,9,16,20-21H,1,8,10H2,2-4H3/t16-,20-,21+/m1/s1 |
| Size | 10mg |
| Supplier Page | https://www.mitochondriasci.com/rotenone-item-628.html |
| Additional Information | Appearance:White to yellow solid |