Auranofin
An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells, and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
| Trivial name | Auranofin (RE1060) |
| Catalog Number | RE1060 |
| Alternative Name(s) | 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate; SKF39162 |
| Research Area | Other/Reagents |
| Molecular Formula | C₂₀H₃₄AuO₉PS |
| Inchi | InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1 |
| Size | 10mg |
| Supplier Page | https://www.mitochondriasci.com/auranofin-item-631.html |
| Additional Information | Appearance:White to off-white solid |