AT-101 R-(-) enantiomer of Gossypol

AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma. It induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway.

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Trivial name	AT-101 (RE1017)
Catalog Number	RE1017
Alternative Name(s)	(-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde; (R)-Gossypol
Research Area	Other/Reagents
Molecular Formula	C₃₀H₃₀O₈
Inchi	InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
Size	10mg
Supplier Page	https://www.mitochondriasci.com/at-101-item-588.html
Additional Information	Appearance:Light brown solid